Directional topography gradients drive optimum alignment and differentiation of human myoblasts
نویسندگان
چکیده
منابع مشابه
Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts.
Pioneer myoblasts generate the first myotomal fibers and act as a scaffold to pattern further myotome development. From their origin in the medial epithelial somite, they dissociate and migrate towards the rostral edge of each somite, from which differentiation proceeds in both rostral-to-caudal and medial-to-lateral directions. The mechanisms underlying formation of this unique wave of pioneer...
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Temporal variation in phenotypic selection is often attributed to environmental change causing movements of the adaptive surface relating traits to fitness, but this connection is rarely established empirically. Fluctuating phenotypic selection can be measured by the variance and autocorrelation of directional selection gradients through time. However, the dynamics of these gradients depend not...
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Proliferation and fusion of myoblasts are needed for the generation and repair of multinucleated skeletal muscle fibers in vivo. We developed a novel cell culture technique that results in formation of myotubes, organized in parallel much like the arrangement in muscle tissue. Alignment and fusion of myoblasts into parallel arrays of multinucleated myotubes are critical in skeletal muscle tissu...
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Single sensor digital cameras capture one color value for every pixel location. The remaining two color channel values need to be estimated to obtain a complete color image. This process is called demosaicing or Color Filter Array (CFA) interpolation. We propose a directional approach to the CFA interpolation problem that makes use of multiscale color gradients .The relationship between color g...
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This paper argues from an Optimality Theory (OT; Prince & Smolensky 1991, 1993; McCarthy & Prince 1993a,b, 1994) perspective that no one-to-one correspondence exists between directional footing effects and individual constraints. Rather, the requirements of a single prosodic alignment constraint may result either in left-to-right or right-to-left footing, depending on its position in a constrai...
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ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2019
ISSN: 1932-6254,1932-7005
DOI: 10.1002/term.2976